Long an under-studied yet widely-used over-the-counter medication, acetaminophen over the last few years is becoming recognized for a range of potential therapeutic uses beyond headache and pain.
One promising area is cardiology, where researchers decided to test the “common wisdom” that acetaminophen had no potential in treating heart disease. This position has been popular in the medical community despite that fact that “there are no in vivo reports on acetaminophen efficacy during myocardial infarction,” a team from Rutgers University notes in the November issue of the American Journal of Physiology-Heart and Circulatory Physiology.
The researchers tested the “gold standard” in the cardiovascular area: “what kind of cardioprotection a medical agent provides, specifically by measuring the infarct size” in a simulated heart attack, according to Gary F. Merrill, the lead author. The team found that acetaminophen significantly reduced the infarct size by 60% or more by three different key measurements in treated dogs, compared with a physiologically identical but untreated control group.
While the heart areas at risk were similar in the two groups, the actual infarct size of untreated animals was 22 grams plus or minus 3g versus 9g ± 2g in treated animals, or about a 60% reduction. Similarly, infarct size expressed as a percentage of the area at risk in untreated hearts was 35% ± 3% versus acetaminophen-treated dogs where it was 13% ± 2%, about a 63% reduction. And when the infarct size was expressed as a percentage of the entire myocardium, the difference in infarct size was equally significant: 8% ± 1% for untreated dogs versus 3% ± 1% for acetaminophen-treated dogs – a 62.5% decrease.
The researchers noted that the “absence of differences in ventricular function and in the general respiratory-metabolic status of the dogs suggests that statistically significant variability in myocardial infarction cannot be explain on the basis of ventricular mechanics, metabolism or respiration.”
They said the results of the current study “extend our recent work in vitro to the in vivo arena and reveal salutary effects of acetaminophen in the neurohumorally intact, blood-perfused tissue environment of the canine myocardium. Results suggest that acetaminophen is among the most efficacious of the cardioprotective agents discovered to date.”
The study, “Acetaminophen and myocardial infarction in dogs,” was written by Gary F. Merrill, Tyler H. Rork, and Norell M. Spiler at the Department of Cell Biology and Neurosciences, Division of Life Sciences, Rutgers University, Piscataway, New Jersey, and Roseli Golfetti of the State University of Sao Paulo at Campinas, Brazil, who was at Rutgers during the research experiments.