A preliminary report suggests that maternal smoking during pregnancy is associated with increased chromosomal abnormalities in fetal cells, according to a study in the current issue of JAMA.
Maternal smoking during pregnancy has many consequences during and after pregnancy, such as infertility, coagulation problems, obstetric complications such as extrauterine pregnancy and placenta previa, and intrauterine growth retardation, according to background information in the article. However, only indirect data have been published on a possible genotoxic (effect of damaging DNA, possibly causing genetic mutation) effect on pregnancy in humans.
Rosa Ana de la Chica, M.Sc., of the Universitat Autònoma de Barcelona, Bellaterra, Spain, and colleagues conducted a study to determine whether maternal smoking has a genotoxic effect on amniotic cells, expressed as an increased chromosomal instability, and analyzed whether any chromosomal regions are especially affected by exposure to tobacco. Fetal amniocytes (cells of fetal origin in the amniotic fluid) were obtained by routine amniocentesis for prenatal diagnosis from 25 controls and 25 women who smoke (10 or more cigarettes/d for 10 or more years). The women were asked to fill out a smoking questionnaire concerning their smoking habits.