Peregrine Pharmaceuticals, Inc., today announced that a research article titled "A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice" was published in the May 15 issue of Cancer Research.
The published report shows that 3G4 (a murine equivalent of the company's Tarvacin monoclonal antibody) in combination with docetaxel results in a 93% inhibition of human breast cancer growth in mouse models. The researchers found that docetaxel increases the exposure of the 3G4 target on tumor blood vessels but not healthy tissue. Patient enrollment in a Tarvacin Phase 1 clinical trial for the treatment of all solid tumors, including breast cancer, is expected to commence this month at three clinical sites.
"Our results suggest that Tarvacin holds promise to be a therapeutic agent that can significantly improve current breast cancer therapy," said Dr. Xianming Huang, the lead author of the report. "While docetaxel is the most important cytotoxic drug currently available for breast cancer, its maximum dose is limited by its toxicity, leaving a pressing need for combination therapies that improve its efficacy without exacerbating its toxicity."
Dr. Huang is an assistant professor of pharmacology in Dr. Philip Thorpe's laboratory at the University of Texas Southwestern Medical Center at Dallas. Further pre-clinical studies studying the potential of Tarvacin in the treatment of drug-resistant breast cancer and in breast cancer metastasis are ongoing at UT Southwestern under a grant by the Susan G. Komen Breast Cancer Foundation and a sponsored research agreement with Peregrine Pharmaceuticals.