People born during a famine in China have an increased risk of schizophrenia, consistent with previous research suggesting a link between fetal nutritional deficiency and schizophrenia, according to a study in the August 3 issue of JAMA: The Journal of the American Medical Association, a theme issue on violence and human rights.
Schizophrenia is a common form of severe mental illness characterized by thought disorder, hallucinations, and delusions, as well a as deterioration of social functioning and social withdrawal, according to background information in the article. It is distributed worldwide with a lifetime risk of approximately 1 percent. Schizophrenia is increasingly viewed as a neurodevelopmental disorder with environmental influences during early brain development modifying risk of schizophrenia. These influences, none of which are yet firmly established, include fetal nutritional deficiency. A previous study found that there was twice the risk of schizophrenia among children conceived during a food shortage in Holland in 1944-1945. However, the number of cases in this study was small, and the findings were only modestly statistically significant.
David St. Clair, M.D., Ph.D., of Shanghai Jiao Tong University, Shanghai, China, and colleagues conducted a study to test the hypothesis that prenatal exposure to famine would increase the rate of schizophrenia in adult life by examining people who lived through a massive famine in China from 1959-1961. The risk of schizophrenia was examined in the Wuhu region of Anhui, one of the most affected provinces. Rates were compared among those born before, during, and after the famine years. All psychiatric case records for the years 1971 through 2001 were examined, and clinical and sociodemographic information on patients with schizophrenia was extracted by researchers.