Women who consume higher doses of non-aspirin painkillers are much more likely to develop high blood pressure than women who do not use them, according to research reported in Hypertension: Journal of the American Heart Association.
"We sought to investigate whether higher doses of analgesic drugs, specifically acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and aspirin, increase a woman's risk of developing new-onset high blood pressure," said lead author John Phillip Forman, M.D., instructor in medicine, Harvard Medical School, and associate physician, renal division, Brigham and Women's Hospital, Boston, Mass. "Because high blood pressure is among the most important causes of death and disease in the United States, and analgesics are the most frequently used medications, a relationship between the two would be important from a public health standpoint."
Researchers studied 1,903 women ages 51-77 who participated in the first Nurses' Health Study, and 3,220 women ages 34-53 from the second Nurses' Health Study. The women did not have high blood pressure when the studies began.
Researchers gathered information about whether the women used analgesic drugs, which type, how much, and why they used them, then tracked whether they subsequently developed high blood pressure. The NSAIDs taken were mostly ibuprofen and naproxen.
"In our study, women who took 500 milligrams (mg) or more of acetaminophen per day, on average, were about twice as likely to develop high blood pressure as women who did not use acetaminophen," Forman said.