A new study shows that combining a technology called optical tomography with standard ultrasound imaging can help distinguish early-stage breast cancer from non-cancerous lesions--and potentially reduce the number of breast biopsies performed. The study appears in the October issue of the journal Radiology.
Ultrasound, which uses reflected sound waves to produce images of the internal structures of the body, is often used to further evaluate suspicious breast lesions found by mammography. But its results are not always reliable enough to avoid a biopsy, in which some of the breast tissue is surgically removed and examined.
"Only 10 to 15 percent of women who undergo a breast biopsy actually have a malignant tumor, leading many women to experience unnecessary anxiety, discomfort and expense," said the study's lead author, Quing Zhu, Ph.D., associate professor of electrical and computer engineering at the University of Connecticut in Storrs.
By combining ultrasound with optical tomography, which employs diffused light in the near infrared (NIR) spectrum, the researchers were able to calculate the concentration of oxygen-carrying blood cells--or hemoglobin--and microvessels present in each lesion. A high density of microvessels in a tumor is known to be highly correlated with malignancy.
"We found that early-stage invasive cancers have a two-fold higher total hemoglobin concentration compared with benign lesions," Dr. Zhu said. "These findings demonstrate that this technique has great potential for non-invasively distinguishing malignant and benign masses to reduce benign biopsies."