Researchers at the Georgia Institute of Technology and the John Innes Centre in the United Kingdom have uncovered a mechanism with which disease-causing bacteria may thwart the body's natural defense responses. The findings, which could ultimately lead to the development of more effective antibiotics, appear in the September 29, 2005 issue of the journal Nature.
"Nitric oxide is produced by the body to fight infections. We discovered a mechanism that allows bacterial cells to detect nitric oxide and turn it into something that's harmless to the cell," said Stephen Spiro, associate professor in the School of Biology at Georgia Tech.
Spiro, along with colleagues Benoît D'Autréauz, Nicholas Tucker and Ray Dixon from the John Innes Centre, studied a non-pathogenic strain of Escherichia coli, which is very closely related to Salmonella bacteria.
The pathogenic forms of E. coli and Salmonella are usually transmitted to humans through undercooked meat, unwashed vegetables and cross contamination from surfaces on which these foods were prepared. Infections from either of these organisms can cause diarrhea, abdominal cramps and sometimes more serious illnesses that require hospitalization. E.coli doesn't respond well to antibiotics, while Salmonella has developed several drug-resistant strains. Learning how the bacteria handle the body's immune response is the first step in developing more effective medicines.