Jefferson researchers have found that mice with low levels of the protein hormone adiponectin may also have high levels of a protein called albumin which, in humans, may be a sign of kidney disease.
This study provides further support for the theory that kidney disease may be a more important risk factor for heart disease than is cholesterol.
Nephrologists at Thomas Jefferson University, Philadelphia, led by Kumar Sharma, M.D., director of Jefferson's Center for Diabetic Kidney Disease, reported on the results during Renal Week in November 2005 at the American Society of Nephrology in Philadelphia.
The researchers worked with two sets of mice. They found a significant negative correlation between the urine albumin and levels of the hormone adiponectin in obese mice. To prove the relationship, they also studied mice without adiponectin ("adiponectin knockout") compared to wild-type mice whose levels were normal. The team found that the knockout mice had three times the level of urine albumin than the wild-type mice.
In a separate study Jefferson researchers measured the adiponectin levels of a group of obese African American adolescents. They found similar results--subjects who had a low level of adiponectin also had the condition known as albuminuria--as indicated by high levels of the protein albumin in their urine. Albuminuria is an indicator for kidney disease.