To detect invasive lung cancer in its early stages, researchers urge current and former smokers who have a strong family history of the disease to take a lung function test and undergo screening with spiral computed tomography. The test is especially important should the previously diagnosed relative be young (around 50).
These findings appear in an article on familial lung cancer in the first issue for January 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
(The screening test, spiral computed tomography, uses a 360-degree X-ray beam, along with computer production of image "slices," to highlight lesions in organs and tissues.)
Ann G. Schwartz, Ph.D., of the Karmanos Cancer Institute in Detroit, Michigan, along with an associate, emphasized that 85 to 95 percent of all lung cancers are attributable to cigarette smoking. The rate of lung cancer in the U.S. has dropped over the past two decades as a result of extraordinary personal and public health smoking cessation efforts. Yet, an estimated 46 million former smokers in America remain at risk for the disease, along with almost 49 million who continue to smoke. Consequently, further efforts need to be made to identify high-risk populations.
"Because cigarette smoking is such an overwhelming risk factor and preventable, the importance of family history and genetic susceptibility to lung cancer risk has been overlooked," said Dr. Schwartz.
She pointed out that individuals with a family history of lung cancer are at approximately a two- to threefold increased risk of developing the illness.
In one screening study, at least one first-degree relative had lung cancer in almost 14 percent of the 26,000 patients diagnosed with the disease.
The authors noted that the median age of onset for younger family members affected by lung cancer was 50 ½, showing a trend toward an earlier age at onset.