A new radiation therapy for prostate cancer -- Cesium-131 brachytherapy -- has fewer side effects than other treatments. NewYork-Presbyterian Hospital/Weill Cornell Medical Center is the only hospital in the Northeast to offer the new therapy.
Brachytherapy involves the implantation of radioactive seeds into the tumor site. Radiation kills or arrests the growth of the cancer with minimal damage to healthy tissue. This helps prevent incontinence and preserve the nerves that allow for erection.
The radioactive isotope Cesium-131, which was approved in 2003 by the FDA for use in brachytherapy for prostate cancer and other malignancies, has several advantages over other isotopes. Compared to Iodine-125 and Palladium-103, it has a higher energy, shorter half-life, and uses a lower total dose of radiation.
Cesium-131 has a half-life of about 10 days, compared to a half-life of 17 days and 60 days for Palladium-103 and Iodine-125, respectively. A shorter half-life means faster dose delivery, that cancer cells have less opportunity to repopulate, and less protracted radiation to normal healthy tissues. The energy emitted by Cesium-131 is stronger than Iodine-125 and Palladium-103 (29 KeV vs. 28 KeV and 21 KeV, respectively). Because the energy is stronger, fewer radioactive seeds are required. This reduces risk of urinary reactions following implantation.