Researchers at Massachusetts Institute of Technology (MIT) have devised a new method for examining how radiation damages normal tissue in the body. The knowledge may make it possible to reduce side effects for cancer patients or to develop treatments for radiation exposure.
About 50 percent of all cancer patients are treated with radiation therapy, either alone or in combination with some other type of treatment. Radiation can be very effective in killing tumor cells, but it also kills normal tissues nearby. In the gastrointestinal (GI) tract, this killing of normal cells can cause such side effects as nausea or diarrhea within days or weeks of treatment, and serious GI tissue damage can occur months or years later.
"The long-term effects that occur six months to a year or more after exposure aren't reversible like the short-term ones, and they are a big unknown," said Associate Professor Jeffrey A. Coderre of MIT's Department of Nuclear Science and Engineering. The damage is similar to scar tissue formation and can seriously affect tissue function in the GI tract.
"We've come up with a tool to selectively irradiate blood vessels to study how radiation damages normal tissue over both the short term and the long term," said Coderre, who is co-author of an article appearing online the week of Feb. 27 in the Proceedings of the National Academy of Sciences (PNAS). "This is the first time it has been possible to do this."
Conventional techniques using external radiation beams are not specific enough for this type of study. "We are selectively delivering a radiation dose to all of the cells that make up the microscopic blood vessels throughout the body," he said.
The method Coderre and his colleagues at MIT and UCLA came up with involves putting boron into a drug administered intravenously in mice, and then subjecting the animals to whole-body neutron radiation using the MIT research reactor. Individual boron atoms in the blood capture a neutron, become unstable, and immediately split in half, giving off two short-range radiations (an alpha particle and a lithium ion) in the process.