Nebivolol, a drug for treatment of high blood pressure available in Europe, may restore damaged cardiovascular functions in African Americans, according to a recent laboratory study at Ohio University.
Tadeusz Malinski, Marvin & Ann Dilley White Professor of Chemistry and Biochemistry, found that the drug, currently under review by the U.S. Food and Drug Administration, acts on the level of oxidants lining the cardiovascular system and can restore levels of nitric oxide and reduce oxidative stress. A deficiency in nitric oxide and high oxidative stress can cause a variety of health problems, including heart attacks, stroke and heart failure, as well as kidney failure and diabetes.
The study was published in a recent issue of Circulation, a journal of the American Heart Association, and involved collaborators from Harvard Medical School and Elucida Research in Massachusetts.
In a healthy cardiovascular system, there is a fine balance between nitric oxide and oxidative stress. Nitric oxide controls blood flow and relaxes blood vessels, which lowers blood pressure. The nitric oxide is released by endothelial cells, a monolayer of cells lining blood vessels.
About a year ago, Malinski's research team discovered that African Americans potentially have a better nitric oxide generating system than people of other ethnicities, the researcher reported. Due to a molecular deficiency, however, the system becomes self-destructive by also generating high concentrations of oxidative species that diminish the level of good nitric oxide and increase oxidative stress to the level observed in a diseased state. The prevalence of this problem can be blamed for the high mortality rate of African Americans between 43 and 64 years of age, which is five to six times higher than that of other ethnic groups, Malinski said.
That's where nebivolol may come in. The drug is part of a new generation of beta-blockers, which are standard treatments for high blood pressure. The researchers studied multiple versions of these beta-blockers and found that, besides lowering blood pressure, nebivolol also restored the function of the nitric oxide system in the cell samples.