A drug used to treat lymphoma, rheumatoid arthritis and other immune disorders may enable newly-diagnosed type 1 diabetics to save some of their pancreas function and thereby reduce their susceptibility to long-term complications.
As the leaders of an international research trial, Indiana University School of Medicine scientists will begin testing the drug, rituximab, starting in April, said Mark Pescovitz, M.D., professor of surgery and of microbiology and immunology. Dr. Pescovitz and Henry Rodriguez, M.D., assistant professor of pediatric endocrinology, will lead the study.
If the drug is effective, it could help prevent some of the long-term complications that plague diabetics, said Dr. Pescovitz. Studies have shown that type 1 diabetics who retain some pancreas function have fewer complications of diabetes, which include heart disease, circulatory problems, loss of vision and kidney damage.
Dr. Pescovitz believes rituximab could be effective because it attacks a key component of the immune system, one that appears to play a role in the development of type 1 diabetes.
Type 1 diabetes develops in children when their pancreas stops making enough insulin, the body's compound used to metabolize sugar. The disease is an immune system disorder in which white blood cells called T-cells turn their attention to their own body's pancreas, attacking it as though it was an external invader. Nobody knows why this occurs.
Normally, T cells attack and ingest infected cells or tumor cells, but only after other immune cells present tiny pieces of the target cells, called antigens, to the T cells. Researchers designed this study based on the hypothesis that white blood cells called B cells serve as the "antigen presenting" cells, picking up antigens from the pancreas as though they were bits of infected cells, and presenting the pancreas antigens to the T cells.
As a result, said Dr. Pescovitz, "The T cells get excited and go back to where the antigens came from -- in this case the pancreas -- and start attacking the pancreas."
Rituximab attacks and destroys the body's B cells, which researchers in the trial hope will stop the body's attack on the pancreas by preventing the B cells from stimulating the T cells into action.
The study will test rituximab in recently diagnosed type 1 diabetes patients who are at least 8 years old and who still have some pancreas function. The patients will receive treatments once a week for four weeks. Two-thirds of the participating patients will receive rituximab, and the rest will receive a placebo.