In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function."
The team, which has been collaborating for over 10 years, reported that it recently "found a very interesting and unexpected phenomenon: various substances which increase mitochondrial size, also increased contractile force of cardiac fibers," or myofibrils. This effect isn't related to the mitochondrial energy production, they noted, and so a hypothesis was developed that "there might be in cardiac cells some form of mechanical signaling between organelles."
Vladimir Veksler, a former Soviet scientist who maintained his contacts with Estonian researchers after moving to Paris, said their latest research "shows that substances increasing the mitochondria can also compress the nuclear organelles, ensuring storage and treatment of genetic information."
Taken together, the results indicate that "the existence of such mechanical signaling between mitochondria and myofibrils opens a new possibility to search for drugs capable of increasing cardiac contractility," Veksler said.
Veksler said the team has been interested for many years in mechanisms of interaction between mitochondria and other organelles. They use "skinned cardiac fibers" whose outer membranes have been chemically removed which allows them to control the intracellular medium. They believed that in the tightly packed myocyte, that "mitochondria could push and compress nearby structures like myofibrils and modulate their functional properties."
This additional evidence of intracellular mechanical signaling "may have important physiological significance," Veksler said. He noted that a "number of studies indicate a sensitivity of nuclei to external mechanical forces and suggest that nuclear deformation could influence gene expression processes. Thus, we hypothesize that drugs or intracellular conditions inducing mitochrondrial swelling could by mechanical means influence gene expression.