Prof. Jens Reich, Biomathematician and member of the German National Ethics Council, is one of the scientists within the Systems Biology competence network HepatoSys 1 who is on the scent of a major mystery of life.
His main concern is the question how biological systems with a vast number of sub-processes can function. In order to understand the linkages, identifying agents such as proteins and encymes does not suffice. Of equal importance is the exploration of their interdependency.
The close collaboration between scientists working in experimental medicine and biology with theorists doing computer modeling in mathematics, physics and engineering sciences has already stood the test. Two years after the launch of the BMBFs funding focus Systems Biology, the networkers of HepatoSys have placed an initial milestone on the way to a virtual liver cell. The aim to reproduce physiological processes not only in vivo (in living organisms) and in vitro (in the test tube), but also in silico 2 (in the computer), has come closer.
First results
The scientists have succeeded in building a mathematical model of the so-called JAK-STAT signal cascade which contributes to the regulation of both the development and the growth control in mammalian cells. With the help of this model they can predict how fast single steps in signal transduction will take place.
Surprisingly, the signal pathway is not linear but occurs in a cyclical manner which is the base for a finely tuned signal transduction.