A review of accumulated evidence on the use of porcine brain choroid plexus (CP) cells published in the July issue of Xenotransplantation highlights that these cells have the potential to treat acute and chronic brain disease.
Successful results of past CP transplants in small animals and primates point to the possibility for treatment of human neurological diseases in the near future.
CP cells are found in the brain and are rich with blood vessels, adjoining with the lining of the brain. The cells produce and secrete hormones that are essential in restoring the health and behavioral capabilities of the brain, eliminate toxic molecules, and are strongly associated with the health of the central nervous system.
The authors of the review reference research demonstrating that a single surgical procedure to implant CP cells can promote recovery of the brain in animal models. The cells used were microencapsulated in alginate-based materials to avoid an immune inflammatory reaction. This one-time administration lasts for six months or more, making this treatment suitable for chronic diseases.