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New bird flu drug will provide new line of defence

Published on November 28, 2006 at 3:52 AM · No Comments

Flu experts say a new flu drug with the ability to kill deadly strains of bird flu promises to provide a much needed third option should a pandemic occur.

The antiviral agent Peramivir may well offer a vital new line of defence against the deadly the H5N1 avian strain which had killed 153 people since 2003 and infected 258 others.

Peramivir could totally transform global preparations for an influenza pandemic as it has been seen in studies to be more powerful and easier to deliver than either Tamiflu or Relenza, the two existing drugs for H5N1 flu.

Experts believe that should H5N1 acquire the ability to pass easily from person to person it could trigger a pandemic and the virus has recently shown signs possibly doing just that.

The World Health Organisation has said as many good antiviral drugs as possible are needed to fight bird flu and having multiple options with different antiviral spectra is very important.

Apparently where Peramivir has the advantage over the other therapies is that it is delivered as an injection while Tamiflu must be taken orally, and Relenza must be inhaled; both therapies are difficult when patients are unconscious.

Also because Peramivir is injected it enters the bloodstream in higher concentrations and remains active for longer.

Tests have also shown that peramivir is effective against every known variant of H5N1, and its greater potency means that the virus is less likely to acquire resistance.

Peramivir would also provide a valuable alternative if a pandemic strain were to evolve with a resistance to Tamiflu.

Tamiflu is currently the front-line treatment and has been stockpiled by many countries, but some H5N1 viruses have already shown resistance to it, and if such a strain became dominant, the drug would become useless.

Scientists have been warning governments for some time that to rely on Tamiflu exclusively would be foolhardy.

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