Scientists test 'secret weapon' against tumours

Published on March 11, 2007 at 6:02 AM · No Comments

Cancer Research UK scientists in Glasgow have devised a new method of attacking cancer cells. They report the findings in the Journal of Clinical Investigation.

A team of scientists from the Beatson Institute for Cancer Research gave mice a chemical that caused cancer cells to commit suicide, significantly slowing the growth of the tumours they were carrying. The chemical kick started a gene called p73 that brings about cancer cell death.

This early research could pave the way for a new agent to stop tumours growing. The researchers suggest that sending the protein - called 37AA - directly into the bloodstream using a 'nanoparticle' delivery system could be a potential way to find and kill tumour cells that have spread as well as those in the primary tumour.

In further laboratory studies the research team found that the chemical could kill several types of cancer cells - including bowel, cervical and bone cells.

Lead researcher Dr Kevin Ryan, a Cancer Research UK senior research fellow and head of the Tumour Cell Death Laboratory at the Beatson Institute, said: "Our study has shown for the first time that the selective activation of a gene called p73 can cause cell death in tumours. We think this approach has the potential to be developed into an effective treatment for cancer."

The gene p73 is related to p53 - one of the most important genes known to protect against the development of cancer. p53, known as the 'guardian of the genome', was first identified by Cancer Research UK scientists in London.

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