Heart attacks are caused by a build-up and instability of plaque in the coronary arteries, which is often a result of chronic inflammation of the blood vessel walls.
A study presented at the American College of Cardiology's 56th Annual Scientific Session assessed whether adding a novel agent with antioxidant and anti-inflammatory properties to optimal medical therapy would reduce coronary events and death among patients with heart disease. ACC.07 is the premier cardiovascular medical meeting, bringing together more than 30,000 cardiologists to further breakthroughs in cardiovascular medicine.
While the trial results did not demonstrate a difference with the use of succinobucol (AGI-1067) versus placebo on the primary endpoint of a composite of major adverse cardiovascular events, the study did achieve a number of other important predefined endpoints, including a reduction in the composite of "hard" atherosclerotic clinical endpoints, composed of cardiovascular death, myocardial infarction (heart attack) and stroke with a relative risk reduction of 19 % (p=0.028); as well as an improvement in several key diabetes parameters, including fewer patients developing diabetes with a relative risk reduction of 64 % (p<0.0001), and better glycemic control (reduction of HbA1c of 0.5% at twelve months, p<0.0001) in patients randomized to succinobucol.
2 - 2 - 2 ALPHA Trial