Performing high-intensity weight-lifting exercise during dialysis sessions brings meaningful improvements in muscle mass, strength, quality of life, and other important health outcomes in patients with end-stage renal disease (ESRD), reports a study in the May Journal of the American Society of Nephrology.
"Our findings suggest that patients who regularly perform resistance training exercise during hemodialysis treatment can significantly improve muscle mass, strength, quality of life, and other aspects of health status that are important to people with kidney failure," comments lead author Bobby Cheema, Ph.D., of University of Sydney, Australia. "We believe that exercise should be integrated as standard practice in dialysis units worldwide."
Muscle wasting is extremely common, and one of strongest risk factors for premature death, in patients with ESRD. "Dialysis patients are very inactive in general and commonly burdened by all of the health risks associated with inactivity, particularly type 2 diabetes and cardiovascular disease," says Dr. Cheema.
Dr. Cheema and colleagues studied the effects of progressive resistance training during hemodialysis in 49 patients with ESRD. One group was randomly assigned to perform high-intensity weightlifting exercise—while seated in the dialysis chair—during regular three-times-weekly dialysis sessions. Using equipment such as dumbbells and ankle weights, the patients did supervised exercises targeting all major muscle groups. The exercises were designed to be "hard" to "very hard"—rated 15 to 17 on the widely used 20-point Borg perceived-exertion scale.
By the end of the 12-week study, patients assigned to weight-lifting had improved muscle mass, as shown by measurements on computed tomography (CT) scans. The CT scans showed decreased fat deposits inside the muscles, suggesting the formation of new muscle tissue—an adaptation associated with broad-ranging health benefits, including improved insulin sensitivity and a longer lifespan.
Other benefits of the exercise program included increased muscle strength, improved perceptions of physical functioning and vitality (i.e., quality of life), and reduced pro-inflammatory markers, which are associated with death from cardiovascular disease and other causes. Patients in the weight-lifting group also had increased body weight, further suggestive of an increase in muscle mass, and clinically meaningful improvements in exercise endurance capacity.