Patients who receive corticosteroids after cardiac surgery have a significantly lower risk of atrial fibrillation in the days following the surgery, according to a study in the April 11 issue of JAMA: The Journal of the American Medical Association.
Atrial fibrillation (AF) is the most common arrhythmia to occur after cardiac surgery. The incidence of AF has been reported to range between 20 percent and 40 percent after coronary artery bypass graft (CABG) surgery and is even higher after heart valve surgery and combined valve and bypass surgery, according to background information in the article. AF is associated with increased illness, including increased risk of stroke and need for additional treatment, with prolonged hospital stay and increased costs. A high inflammatory response after surgery has been thought to be partly responsible for AF.
Jari Halonen, M.D., of Kuopio University Hospital, Kuopio, Finland, and colleagues conducted a randomized multicenter trial to test whether intravenous corticosteroid administration prevents AF after cardiac surgery. The study, conducted at three university hospitals in Finland, included 241 patients without prior AF who were scheduled to undergo CABG surgery, aortic valve replacement, or combined CABG surgery and aortic valve replacement. Patients were randomized to receive either 100-mg hydrocortisone or matching placebo the evening of the operative day, then 1 dose every 8 hours during the next 3 days.