Morphine, as little as a single dose, blocks the brain's ability to strengthen connections at inhibitory synapses, according to new Brown University research published in Nature.
The findings, uncovered in the laboratory of Brown scientist Julie Kauer, may help explain the origins of addiction in the brain. The research also supports a provocative new theory of addiction as a disease of learning and memory.
"We've added a new piece to the puzzle of how addictive drugs affect the brain," Kauer said. "We've shown here that morphine makes lasting changes in the brain by blocking a mechanism that's believed to be the key to memory making. So these findings reinforce the notion that addiction is a form of pathological learning."
Kauer, a professor in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown, is interested in how the brain stores information. Long-term potentiation, or LTP, is critical to this process.
In LTP, connections between neurons , called synapses, the major site of information exchange in the brain , become stronger after repeated stimulation. This increased synaptic strength is believed to be the cellular basis for memory.
In her experiments, Kauer found that LTP is blocked in the brains of rats given as little as a single dose of morphine. The drug's impact was powerful: LTP continued to be blocked 24 hours later , long after the drug was out of the animal's system.
"The persistence of the effect was stunning," Kauer said. "This is your brain on drugs."