Parkinson's disease, also known as shaking palsy, is one of the most frequent diseases of the nervous system.
Cell death of neurons in specific regions of the midbrain is leading to the onset of the disease. However, the the causes for this extensive cell death are unknown. Especially in cases of early manifestation of the disease mutations in the so-called parkin gene are of great significance. In a collaborative effort the groups of Dr. Konstanze Winklhofer (Ludwig-Maximilians-University Munich) and Dr. Daniel Krappmann (GSF – Research Center for Environment and Health, Neuherberg) have now been able to reveal a novel function for the Parkin protein.
The scientists could show that Parkin prevents the induction of neuronal cell death. As reported in the “Journal of Neuroscience“, the protein activates a survival mechanism which had been known for its prominent role in immune response.
Usually, Parkinson’s disease occurs after the age of 50 and in Germany about 400,000 people are affected. It is characterized by a decline of neurons in the so-called Substantia Nigra, a structure in the midbrain that produces dopamine. The resulting deprivation of this messenger substance causes symptoms like muscular tremor at rest and restricted mobility and even complete immobility. Characteristic deposits are found in the brain, the Lewy corpuscles.
Little is known about the causes of Parkinson’s disease. It has only been known for a few years that ten to fifteen per cent of all cases are associated with mutations in certain genes.
“The parkin gene is of special interest here”, says Winklhofer. “One effect of its inactivation is that the Parkin protein loses its physiological function. This genetic defect plays a role for hereditary Parkinson’s disease, which may lead to an early onset of the disease.”