Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. In a report in Developmental Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.
"The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is maturing," says Denise Montell, Ph.D., professor of Biological Chemistry and director of the Center for Cell Dynamics. "What these border cells are doing resembles what cancer cells do when they migrate from the main growth to other tissues."
The historic problem, Montell says, is that it's been impossible to watch this process inside the ovarian tissue no microscope can do that and worse, the cells stop moving if they're outside the ovaries. In a years-long effort, Montell and her team figured out just what to feed these cells to keep them alive and doing their thing without their ovarian homes.
"We were stuck having to watch this through a series of still pictures and losing a lot of the story, "Montell says. "Now with real-time movies, we're deciphering the nuances behind organized cell movement that should offer opportunities for hopefully regulating the process."