Pycnogenol reduces perimenopausal symptoms

A study to be published in an upcoming edition of the Scandinavian Journal of Obstetrics and Gynaecology reveals that Pycnogenol (pic-noj-en-all), pine bark extract from the French maritime pine tree, reduces "climacteric symptoms" such as hot flashes, depression, panic attacks, cholesterol and other common symptoms associated with women entering menopause transition.

The results suggest Pycnogenol may serve as an alternative treatment to estrogen replacement therapy, which is the most common remedy of pre-menopause (“perimenopausal”) symptoms.

According to the U.S. Department of Health and Human Services, perimenopause is the natural part of aging that signals the ending of a woman's reproductive years. It marks the time when a woman's body begins its move into menopause and can last anywhere from two to eight years.

“Pycnogenol was chosen for this study due to previous research revealing health benefits associated with cognitive function, skin elasticity, nitric oxide stimulation, free radical scavenging and the broadening of antioxidant activity,” said Dr. Peter Rohdewald, Institute of Pharmaceutical Chemistry at Germany's University of Munster and a lead researcher of this study. “Achieving these health benefits is key to treating perimenopausal symptoms naturally.”

The randomized, double-blind, placebo controlled study was conducted at Ham-Ming Hospital in Taiwan with 155 perimenopausal women. Each day, patients either received 200 mg Pycnogenol or placebo, and recorded their symptoms using the Women's Health Questionnaire (WHQ). The WHQ consisted of the following: somatic symptoms, depressed mood, vasomotoric symptoms, memory/concentration, attractiveness, anxiety, sexual behavior, sleep problems and menstrual symptoms.

Additionally, patients visited the clinic at one, three and six months following start of treatment. At each visit, BMI, blood pressure, lipid profile and total antioxidant status were recorded.

After six months, LDL (bad) cholesterol dropped by 10 percent with Pycnogenol treatment compared to placebo. Patients who supplemented with Pycnogenol also had increased antioxidant levels compared to the placebo group. During treatment, rapid improvement of symptoms was reported from the Pycnogenol group after one month. All symptoms of the WHQ improved significantly compared to the start of treatment, and patients did not report unwanted side effects. In the placebo group, no significant changes of symptoms were recorded.

“There is a shift away from the use of hormone replacement therapy due to side effects and in its absence women are searching for safe and natural options to help manage their symptoms. This study investigating Pycnogenol as a potential natural alternative is very encouraging in view of the safety of Pycnogenol as it does not bear any hormone-like activities at all,” said Dr. Rohdewald.

Numerous other published studies reveal Pycnogenol's effectiveness for women's health, such as relieving menstrual pain and endometriosis, and it is patent-protected for this application. Additional studies reveal Pycnogenol is a natural anti-inflammatory, which provides the basis for the rationale to use Pycnogenol to naturally moderate inflammatory pain sensation involved in menstruation.