Using a molecular cellular compass, individual cells in complex organisms know which way is up or down, in epithelial cells known as apical-basal polarity.
Determining the orientation is essential for an individual cell to perform it’s designated tasks. Now it appears that the same compass also defines the direction of cells when migrating by establishing a morphological back and a front. These are the conclusions of a recent study lead by scientists Michiel Pegtel and John Collard from the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) in the Netherlands published in the October 9th issue of the scientific journal Current Biology.
Many cell types acquire asymmetry for their biological function. Yeast cells, worms, mice and men all use the same cellular compass, made up of a combination of protein complexes that is essential for the spatial orientation of the cell. The Par-Tiam1 polarity complex is a crucial component of the compass. Tiam1 was earlier identified as a gene that could influence dissemination of tumour cells.
In a previous study by the group of John Collard from the NKI-AVL, it became clear that the Par-Tiam1 complex is crucial for top/bottom orientation of adherent cells. This form of cell asymmetry is required for the cells to properly adhere and to form a tightly connected cellular structure. However, loss of orientation or cell polarity leads dissociation of cell-cell contacts and in tumours to dissemination of cancer cells.