Young people whose mothers drank when pregnant may be more likely to abuse alcohol because, in the womb, their developing senses came to prefer its taste and smell.
Researchers with the State University of New York Developmental Ethanol Research Center have found that because the developing nervous system adapts to whatever mothers eat and drink, young rats exposed to alcohol (ethanol) in the womb drank significantly more alcohol than non-exposed rats.
These findings, covered in two related studies, appear in the December issue of Behavioral Neuroscience, published by the American Psychological Association (APA). The studies contribute a critical biological piece to the complex puzzle of why teens with a family history of drinking may themselves drink more. Lead author Steven Youngentob, PhD, observes that a biologically instilled preference for alcohol's taste and smell can make young people much more likely to abuse alcohol, especially in light of social pressures, risk-taking tendencies and alcohol's addicting qualities.
These more subtle consequences of fetal alcohol exposure come on top of the potential for Fetal Alcohol Syndrome, which leads to profound neurodevelopmental problems including mental retardation.
In one study, infantile rats exposed to alcohol (ethanol) in the womb drank significantly more of it in youth but not in adulthood. They were the offspring of dams, or mother rats, from one of three experimental groups: ethanol-exposed via the mother's diet at levels simulating moderate to heavy drinking; pair-matched controls that ate the same amounts as ethanol exposed-dams to control for any effect of under-nutrition; and controls that ate freely.
The offspring were studied at Day 15 after birth, still infants, or Day 90 after birth, fully mature. Adult rats chose to drink ethanol or non-ethanol solutions, both from bottles. Rat pups were presented with ethanol solutions through tubes implanted in their cheeks; they could either swallow to accept, or reject it by shaking their heads, licking the chamber walls or floor, or letting it drip out.
The ethanol-exposed animals drank significantly more ethanol than both groups of control animals. The authors cite their finding as evidence for ethanol preference resulting from maternal use or abuse of ethanol during pregnancy.
The authors put forth the idea that when the developing nervous system senses ethanol in amniotic fluid, it adapts without awareness of which chemicals will help or hurt the organism. It could be alcohol; it could be carrot juice; the adaptation is the same. Given the former, the olfactory system of a developing fetus becomes attuned to ethanol's chemosensory attributes. It “likes” the taste and smell, two big factors in the flavor of alcohol. However, Youngentob further suggests that if the nervous system has no further experience with the drug by adulthood, ethanol loses its chemosensory allure.