According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight.
Excessive weight gain is elicited by alterations in energy balance, the finely modulated equilibrium between caloric intake and expenditure. But what are the factors that determine how much food is consumed" Part of the mystery is unfolding in the laboratory of Maribel Rios, PhD, at the Sackler School of Graduate Biomedical Sciences at Tufts University School of Medicine in Boston. Through their work, Rios and colleagues have demonstrated for the first time that a protein called brain-derived neurotrophic factor (BDNF) is critical in mediating satiety in adult mice. Their findings are published in the December 26 issue of The Journal of Neuroscience.
Mice in which the Bdnf gene was deleted in two of the primary appetite-regulating regions of the brain ate more and became significantly heavier than their counterparts. “Prior to this study, we knew that the global lack of BDNF and/or its receptor during development leads to overeating and obesity in young mice. However, it remained unclear and controversial whether BDNF mediated satiety in adult animals. Our recent findings demonstrate that BDNF synthesis in the ventromedial (VMH) and dorsomedial hypothalamus (DMH) is required for normal energy balance. Additionally, because the mice examined in this study were genetically altered in adulthood, we were able to establish that BDNF acts as a satiety signal in the mature brain independently from its putative actions during development of the brain. This important distinction might help define disease mechanisms and critical periods of intervention for the treatment and prevention of obesity disorders,” says Rios, corresponding author and an assistant professor of neuroscience at the Sackler School.
The obesity exhibited by BDNF-depleted mice appears to arise solely from overconsumption of calories. “Normal body weight was restored in mutant mice when food access was limited to that of normal mice, indicating that deletion of the Bdnf gene in the VMH and DMH does not affect the expenditure side of the energy balance equation,” adds Rios.