A new study has found that cigarette smoking and alcohol consumption do not have an effect on ovarian cancer risk, while caffeine intake may lower the risk, particularly in women not using hormones.
The study is published in the March 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society.
Various studies have assessed the potential link between modifiable factors such as smoking or caffeine and alcohol intake and have generated conflicting results. To help clarify these associations, Dr. Shelley S. Tworoger, of Harvard Medical School and the Harvard School of Public Health, and colleagues examined ongoing questionnaire data from the Brigham and Women's Hospital-based Nurses' Health Study, which includes 121,701 US female registered nurses. The Nurses' Health Study cohort was established in 1976, when women aged 30-35 completed and returned initial questionnaires. Every two years, questionnaires are sent to the women to update exposure variables and document newly diagnosed diseases.
Dr. Tworoger and her co-investigators prospectively examined associations between smoking and ovarian cancer risk among 110,454 women and between alcohol or caffeine and ovarian cancer risk among 80,253 women, all followed between June 1, 1976 and June 1, 2004. For the smoking analyses, they identified 737 confirmed cases of epithelial ovarian cancer, and for the dietary analyses, they identified 507 cases.