Scientists have discovered how low levels of a protein hormone found in body fat, plays a crucial role in tumour growth and spread. Their findings are published in a paper in the British Journal of Cancer.
Postmenopausal women who are overweight are at greater risk of developing breast cancer, as large amounts of body fat secrete much higher levels of the hormone oestrogen and the growth factor leptin, which can encourage tumours to grow. New research in mice and breast cancer cell lines, from scientists at the Hormel Institute, University of Minnesota, shows how low levels of a protein hormone called adiponectin or Acrp30 may help to trigger the disease.
The study, the first to examine and clarify the role played by two different forms of Acrp30, full length (Acrp30) and globular (gAcrp30), in tumour growth, is further evidence of an obesity link to breast cancer.
Previous research into adiponectin, which is only found in body fat, has shown that levels increase when individuals lose weight, either through dieting or as the result of gastric bypass surgery. Reduced levels of Acrp30 have also been linked with other diseases influenced by diet such as type 2 diabetes and coronary artery disease.