Taking the supplement ginkgo biloba had no clear-cut benefit on the risk of developing memory problems, according to a study published in the February 27, 2008, online issue of Neurology, the medical journal of the American Academy of Neurology.
The three-year study involved 118 people age 85 and older with no memory problems. Half of the participants took ginkgo biloba extract three times a day and half took a placebo. During the study, 21 people developed mild memory problems, or questionable dementia: 14 of those took the placebo and seven took the ginkgo extract. Although there was a trend favoring ginkgo, the difference between those who took gingko versus the placebo was not statistically significant.
The researchers made an interesting observation when they examined the data at the end of the trial. Taking into account whether people followed directions in taking the study pills, they found that people who reliably took the supplement had a 68 percent lower risk of developing mild memory problems than those who took the placebo. Without further study, it is unclear if this difference is real or just a chance occurrence.