Persons infected with a mutated HIV strain, transmitted from those who have the genetic advantages to control the virus, results in improved survival according to a recent study by South African researchers.
The study, published March 21st in the open-access journal PLoS Pathogens, looked for genetic mutations in the infecting virus in 24 newly infected people in Durban, South Africa.
The study was conducted by CAPRISA (the Centre for the AIDS Program of Research in South Africa) researchers at the Universities of Cape Town, KwaZulu-Natal, Western-Cape and the National Institute of Communicable Diseases in South Africa. According to Professor Salim Abdool Karim, Director of CAPRISA, “It is significant that the mutations to HIV which occur in a person with advantageous genes leads to a low viral load, even when the virus infects a new person who does not have these ‘good' genes. Low viral load is a goal of several HIV vaccines as it means that these HIV infected people will be clinically well for longer and be less likely to spread the virus.”
HLA genes affect the rate of disease progression in HIV-infected individuals, alerting the immune system to HIV's presence. HIV can evade the immune system by mutating into forms unrecognizable by the HLA. However, it is known that some people have versions of the HLA gene (for example HLA-B*57 and HLA-B*5801) that can only be evaded by the virus if it mutates to a form that has a reduced replication rate.