World leading scientists are to be targeted by Cancer Research UK and its development and commercialisation arm Cancer Research Technology (CRT), in an effort to tackle some of cancer's most pressing scientific challenges.
The initiative will see the charity hand pick 'crack teams' of up to five world class scientists - each a leader in their own discipline - who will be joined by some of the world's foremost pharmaceutical companies. The teams will focus on an emerging cancer field identified by Cancer Research UK, and work towards translating basic science into new treatments and diagnostic tools to help beat cancer.
The first project, which will look at utilising cellular senescence - putting cancer cells to sleep to prevent the spread of cancers such as melanoma, has been identified - and a team of UK-based scientists put in place. The team has the expertise to harness this natural phenomenon and design tests to 'screen' for new potential drugs that can kick-start senescence in cancer patients. Two further projects are planned for 2009 and 2010, which will focus on cancer stem cells and the histone code, respectively.
Each new project will form a limited company, managed by CRT's business team. Initially the projects will receive up to half a million pounds from Cancer Research UK over a two-year period. It is hoped each team will attract an industry partner which will bring know-how and further finance to the project. In return they will benefit by becoming a shareholder in the company and draw on Cancer Research UK's expertise in translating basic scientific discoveries into new treatments for cancer.
Once the early development phase is complete, the industrial partner has the option to acquire the company and progress any joint discoveries into clinical compounds.
CRT's senior business manager and scheme leader, Simon Youlton, said: "This initiative creates a unique opportunity for us to hand-pick a 'crack team' of scientists wherever they may be based - rather than being tied to a particular academic institution or team which approaches us for funding.
"It enables us to pose an industrially relevant problem that Cancer Research UK wants solving and we hope it will help bridge the gap between academia and industry by combining commercial and scientific know how with the best and most dedicated brains in science."
Any profits arising from the success of the work will be shared between the charity and the research partners involved, with Cancer Research UK re-investing any proceeds in its future research work. The business relationships will be managed by CRT, who have more than 20 years experience in licensing patents and developing opportunities for new cancer drugs and diagnostics, working closely with licensees and the pharmaceutical industry.