Cancer Research UK scientists have shown that it may soon be possible to offer women a genetic test to assess their risk of breast cancer which could aid early diagnosis for those at high risk of the disease. Their findings are revealed in the New England Journal of Medicine today (Wednesday).
Cancer Research UK funded scientists from the University of Cambridge, looked at the seven common 'modest risk' gene sites which, in combination, put women at increased risk of developing breast cancer. They wanted to see what impact testing women for these genes might have on future public health policy - such as lowering or increasing the age at which they start to be screened for breast cancer and targeting lifestyle advice to women to reduce their risk of developing the disease.
Study author Dr Paul Pharoah, from the University of Cambridge, said: "We are a few years away from a new and powerful range of genetic tests for breast cancer. We believe genetic testing has the potential to enable doctors to identify a woman at an increased risk of breast cancer who would benefit from mammography at an early age or woman who may benefit from regular MRI scanning as well. This approach would also identify a 55 year old woman with a low chance of breast cancer who possibly wouldn't need such regular checks."
Currently doctors only test women who have a very strong family history of breast cancer for the high risk breast cancer genes such as BRCA1, BRCA2, PTEN, and TP53. But these gene faults are rare and few women in the general population will benefit from such testing. In contrast, genes that give woman a slightly increased risk are common and although each one has little impact alone, testing for their combination could prove useful.