Prehypertension during young adulthood is common and is associated with subsequent coronary atherosclerosis, according to a study published in today's issue of Annals of Internal Medicine.
Researchers from the University of California, San Francisco, analyzed blood pressure measurements of 3,560 adults aged 18 to 30 from seven examinations over the course of 20 years. Nearly 20 percent (635) of the study participants developed prehypertension (systolic blood pressure 120 to 139 mmHg or diastolic blood pressure 80 to 89 mmHg) before the age of 35.
Although these blood pressure levels are below the cutoff for hypertension, the young adults with prehypertension were more likely than those with lower blood pressure to have calcium in their coronary arteries later in life. Coronary calcium is a marker of atherosclerosis and a predictor of future heart attacks and strokes.
"Our findings suggest the possibility that prehypertension itself is harmful, and not just because it is associated with subsequent hypertension," said Mark J. Pletcher, MD, MPH, the study's lead author. "People with a lot of calcium in their coronary arteries are more likely to have heart attacks and strokes, and these outcomes might be avoidable by keeping blood pressure low when you're young."
Dr. Pletcher notes, however, that the study only shows an association between prehypertension in young adults and coronary calcium later in life, and that blood pressure medications have not been proven to prevent cardiovascular disease in young adults with prehypertension.