The Biotechnology and Biological Sciences Research Council (BBSRC) has awarded a grant of over £0.5 million to groups in the Laboratories for Integrative Neuroscience and Endocrinology and the MRC Centre for Synaptic Plasticity (project leader, Professor Kei Cho). The funding will support research into how brain cells maintain their performance, and create memories, during periods of acute stress.
This important research cuts across disciplines - namely endocrinology (study of hormones) and neuroscience - to see how stress hormones, especially glucocorticoids, act in the brain. The University's Bristol Neuroscience network (BN) is key in ennabling this kind of work, since it exists to bring diverse disciplines together.
Professor Stafford Lightman, joint grant-holder, said: 'At a time of stress - such as seeing a lion advancing on you, or maybe even a double-decker bus - it is important for your brain to work optimally and to find the best way to escape. Clarity of assessing the situation is therefore paramount. It is also critically important to remember and learn from the situation; if it recurs, you can refer to the earlier experience and know how best to escape.'
Research supported by the grant should also shed light on what happens in the brain during the long-term chronic stress related to work or personal problems.
Professor Graham Collingridge in the Department of Anatomy commented: 'Professor Lightman and I co-founded BN five years ago to promote dialogue within Bristol's diverse neuroscience community. I am delighted that one of the resulting collaborations is a joint project between our labs, headed by Professor Kei Cho, whose appointment can also be directly attributed to BN.'
Bristol Neuroscience