According to new research from the U.S. controlling the level of a fatty acid in the brain could help treat Alzheimer's disease (AD).
Scientists at the Gladstone Institute of Neurological Disease at the University of California, San Francisco, who were researching the brain changes that lead to Alzheimer's, suggest that reducing excess levels of the acid could influence memory problems and behavioural changes.
In research using mice the researchers examined the fatty acids in the brains of normal mice and compared them with those in mice genetically engineered to have an Alzheimer's-like condition and they identified raised levels of the fatty acid arachidonic acid in the brains of the Alzheimer's mice - the release of arachidonic acid is controlled by the PLA2 enzyme.
Fatty acids are rapidly taken up by the brain and incorporated into phospholipids, a class of fats that form the membrane or barrier that shields the content of cells from the external environment, by an enzyme called group IVA phospholipase A2 (or PLA2).
The scientists found that the removal or even partial reduction of PLA2 prevented memory deficits and other behavioral abnormalities in the Alzheimer mice and they believe fatty acid levels could be controlled through diet or drugs.
AD causes a progressive loss of cognitive functions resulting in death and millions worldwide are struggling to live with the condition; although there are treatments to ease the symptoms, these treatments are not very effective and researchers have yet to discover a cure.