Hospital-acquired infections that are resistant to traditional antibiotic treatment have become increasingly common in recent years, confounding health care professionals and killing thousands of Americans.
Now, in studies that could lead to new ways to prevent this growing public health danger, a team of University of Cincinnati (UC) researchers is exploring a "zinc zipper" that holds bacterial cells together and plays a key role in such infections.
Hospital-acquired infections affect about 1.7 million people per year in the United States and result in an estimated 99,000 deaths annually, according to the Centers for Disease Control. About two-thirds of all hospital-acquired infections can be traced to two staphylococcal species, Staphylococcus aureus-including methicillin-resistant strains (MRSA) that are particularly difficult to treat-and Staphylococcus epidermidis.
In an article appearing in the Dec. 1 online edition of Proceedings of the National Academy of Sciences, researchers in UC's department of molecular genetics, biochemistry and microbiology detailed findings that the presence of zinc is crucial to the formation of infection-causing biofilms.
Staphylococci can grow as biofilms, which are specialized communities of bacteria that are highly resistant to antibiotics and immune responses. They are remarkably adhesive and can grow on many surfaces, including implanted medical devices such as pacemakers, heart valve replacements and artificial joints. Preventing or inhibiting the growth of such biofilms would dramatically reduce the incidence of staph infections.