It is estimated that 4 million people world-wide are suffering from Parkinson's, a complex disease that varies greatly among affected individuals.
Understanding the brain chemistry that leads to the onset of Parkinson's is vital if we are to develop methods for early MRI diagnosis and new treatments for this devastating disease.
Speaking at the AAAS Meeting in Chicago, Dr Joanna Collingwood, from Keele University, will present new results from studies carried out, in collaboration with Dr Mark Davidson from the University of Florida (UF), at Diamond - the UK's national synchrotron. Their results show that the distribution of metal ions in the brain tissue of sufferers is altered by the disease process. By studying the tissue as a whole, it has been possible to map metal distribution throughout the brain region containing the vulnerable motor neurones in Parkinson's disease in a region where they had earlier shown that iron levels nearly double in individual cells [Oakley 2007]. The primary support for this research is provided by the Engineering and Physical Sciences Research Council (EPSRC) in the UK.
Dr Collingwood comments, "Our studies at Diamond involve a technique called microfocus spectroscopy, in which powerful, tightly focussed beams of X-rays penetrate our tissue samples. We have been able to investigate human tissue with such precision that metal ions, particularly iron levels, in and around individual cells can be mapped. What makes the microfocus synchrotron approach so unique is that we can also use the focussed beam to obtain information about the form in which the iron is stored. Thanks to several years of work on optimizing the tissue preparation method at the Materials Research Collaborative Access Team at the Advanced Photon Source (APS) led by Dr. Davidson and Drs. Jon Dobson, of Keele and Chris Batich of UF, the technique is pioneering in that it does not change the distribution or form of the metals in the tissue being studied. We are grateful to the National Institutes of Health (NIH) in the USA for supporting this vital work. The impact of tissue preparation on the metal ions has been overlooked in many research projects in this area to date".