In an attempt to decrease the amount of cancer-targeting nanoparticle needed to image tumors, a team of investigators at the Massachusetts General Hospital and Harvard Medical School has developed a simple method for creating iron oxide nanoparticles labeled with 18F, a radioisotope that is easily detected using positron emission tomography (PET). The result is a nanoparticle that can be imaged using PET, computerized tomography (CT), and fluorescence imaging.
A research team headed by Ralph Weissleder, M.D., Ph.D., principal investigator of the MIT-Harvard University Center for Cancer Nanotechnology Excellence, reported the results of its work in the journal Bioconjugate Chemistry.
Adding 18F to nanoparticles is a major challenge to the development of cancer probes that can be imaged using PET. Dr. Weissleder and his collaborators overcame this obstacle by using a novel chemical reaction known as "click chemistry." Click chemistry can add fluorine atoms to complex biomolecules or nanoparticles using very mild reaction conditions that do not damage biocompatible constructs. This reaction also proceeds quickly, an important consideration given that the half-life of 18F is only 110 minutes.