Results from a new sub-analysis of the JUPITER study show that patients who attained a dual treatment target of LDL-C <70mg/dL and high-sensitivity C-reactive protein (hsCRP) <2mg/L with CRESTOR (rosuvastatin) 20mg achieved a greater reduction in cardiovascular events compared to placebo than those who did not (65% vs 36%, p=0.033) among men and women with low to normal cholesterol levels and elevated hsCRP.
These new data were presented at the 58th Annual American College of Cardiology Scientific Sessions (ACC) in Orlando, Florida, and published simultaneously in The Lancet.
This analysis was conducted in approximately 15,500 patients, or 87% of the entire JUPITER cohort, representing patients who had LDL-C and hsCRP values assessed at baseline and one year.
Additional results from this analysis showed: -- Patients who achieved an LDL-C <70 mg/dL experienced a 55% reduction in cardiovascular events compared to placebo. -- Patients who achieved a dual treatment target of LDL-C<70 mg/dL and hsCRP <1 mg/L achieved a 79% reduction in CV events compared to placebo.
"These data further support the benefit of achieving low LDL-C with rosuvastatin," said Michael Cressman, AstraZeneca's Medical Science Director for CRESTOR, "Raised LDL-C is one of the major causes of atherosclerosis, an underlying cause of cardiovascular disease. Elevated CRP is a recognized marker of inflammation, so this analysis also suggests that in addition to its lipid lowering properties, CRESTOR may impact another aspect of atherosclerosis, inflammation."
Rosuvastatin 20mg was well tolerated in nearly 9,000 patients during the course of the JUPITER study.
Rosuvastatin is not indicated for the prevention of cardiovascular events. Rosuvastatin should be used according to the prescribing information, which contains recommendations for initiating and titrating therapy according to the individual patient profile. In most countries, the usual recommended starting dose of rosuvastatin is 10 mg.
ABOUT JUPITER:
Results from the primary analysis of JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin), originally presented in November 2008 at the American Heart Association's Annual Scientific Sessions, and published by the New England Journal of Medicine, showed rosuvastatin 20mg significantly reduced major cardiovascular (CV) events (combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by 44%, compared to placebo (p<0.00001). These results also showed that rosuvastatin 20 mg reduced the combined risk of heart attack, stroke or CV death by nearly half (47%, p<0.00001 vs placebo).