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Bad mix of bacterial remnants and NOD2 gene lead to arthritis

Published on April 1, 2009 at 10:32 AM · No Comments

Here's another reason to hate leftovers. A research study appearing in the April 2009 issue of the Journal of Leukocyte Biology sheds light on one cause of arthritis: bacteria.

In the study, scientists from the United States and The Netherlands show that a specific gene called NOD2 triggers arthritis or makes it worse when leftover remnants of bacteria cell walls, called muramyl dipeptide or MDP, are present. This discovery offers an important first step toward new treatments to prevent or lessen the symptoms of inflammatory arthritis.

"Despite recent advances in the treatment of arthritis, none target its cause," said Michael Davey, Associate Chief of Staff for Research at the Portland Oregon Veteran's Affairs Medical Center and one of the researchers involved in the study. "Our work with MDP and NOD2 is a step toward understanding the root cause of arthritis which one day may allow certain forms of arthritis to be prevented altogether."

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