Killing only older mosquitoes could be a more sustainable way of controlling malaria, and has the potential to lead to evolution-proof insecticides that never become obsolete, according to an article in this week's issue of PLoS Biology.
Each year, malaria - spread through mosquito bites - kills around a million people, and many of the chemicals used to kill the insects become ineffective as the mosquito's resistance to them evolves. New theoretical work, by Andrew Read and Matt Thomas (both at Penn State), and Penelope Lynch (Open University, UK), predicts that simple changes to the way insecticides are used could prevent the evolution of resistance and thereby reduce the burden of malaria. The authors argue that insecticides - chemical or biological - which kill only older mosquitoes, are a more sustainable way to fight the deadly disease.
Read says the development of biological or chemical insecticides that target older, malaria-infected mosquitoes could save millions dollars that would otherwise be spent endlessly looking for new insecticides to replace ones that have become ineffective. "Done right, a one-off investment could create a single insecticide that would solve the problem of mosquito resistance forever."
"Insecticides sprayed on house walls or bed nets are some of the most successful ways of controlling malaria," says Professor Read, professor of biology and entomology at Penn State, "but they work by killing the insects or denying them the human blood they use to make eggs. This imposes an enormous selection in favor of insecticide-resistant mosquitoes."
However, once malaria parasites infect a mosquito, they need at least 10 to 14 days - or two to six cycles of egg production - to mature and migrate to the insect's salivary glands. From there they can pass into humans when a mosquito bites. Therefore, as Read explains, "Most mosquitoes do not live long enough to transmit the disease. To stop malaria, we only need to kill the old mosquitoes."
To study the impact of late-acting insecticides on mosquito populations, the researchers constructed a mathematical model of malaria transmission using factors such as the egg laying cycle of the mosquito and the development of parasites within the insect. Analyses of the model using data on mosquito lifespan and malaria development from hotspots in Africa and Papua New Guinea reveal that insecticides killing only mosquitoes that have completed at least four cycles of egg production reduce the number of infectious bites by about 95 percent. Critically, the researchers also found that resistance to late-acting insecticides spreads much more slowly among mosquitoes, compared to conventional insecticides, and that in many cases, it never spreads at all.