For the first time, researchers have clearly shown regeneration of a critical type of nerve fiber that travels between the brain and the spinal cord and which is required for voluntary movement.
The regeneration was accomplished in a brain injury site in rats by scientists at the University of California, San Diego School of Medicine and is described in a study to be published in the April 6th early on-line edition of the Proceedings of the National Academy of Sciences (PNAS).
"This finding establishes a method for regenerating a system of nerve fibers called corticospinal motor axons. Restoring these axons is an essential step in one day enabling patients to regain voluntary movement after spinal cord injury," said Mark Tuszynski, MD, PhD, professor of neurosciences, director of the Center for Neural Repair at UC San Diego and neurologist at the Veterans Affairs San Diego Health System.
The corticospinal tract is a massive collection of nerve fibers called axons - long, slender projections of neurons that travel between the cerebral cortex of the brain and the spinal cord, carrying signals for movement from the brain to the body. Voluntary movement occurs through the activation of the upper motor neuron that resides in the frontal lobe of the brain and extends its axon down the spinal cord to the lower motor neuron. The lower motor neuron, in turn, sends its axon out to the muscle cells. In spinal cord injuries, the axons that run along the corticospinal tract are severed so that the lower motor neurons, below the site of injury, are disconnected from the brain.
"Previous spinal cord injury studies have shown regeneration of other nerve fiber systems that contribute to movement, but have not convincingly shown regeneration of the corticospinal system," said Tuszynski, theorizing this was due to a limited intrinsic ability of corticospinal neurons to turn on genes that allow regeneration after injury. He added that, without regeneration of corticospinal axons, it is questionable whether functional recovery would be attainable in humans.