Regular exercise can prevent the disruption of the blood brain barrier that normally occurs with a dose of methamphetamine comparable to that used by heavy meth users.
A University of Kentucky study is the first to look at the protective effects of exercise on the vascular effects of methamphetamine, effects that have been found clinically to contribute to serious, lasting, and sometimes fatal cardiovascular and neurological problems. Results of the study, conducted in young male mice, were reported April 22 at the Experimental Biology 2009 meeting in New Orleans. The presentation was part of the scientific program of The American Physiological Society.
Principal investigator Dr. Michal Toborek says the level of the protective effects of exercise on the integrity of the blood brain barrier after the human equivalent of one gram of methamphetamine was surprising even to the research team.
The results provide new understanding of the mechanisms through which the brain reacts to methamphetamine, particularly those related to oxidative stress. Results also suggest why exercise might help delay the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's in which leakiness of the blood brain barrier is a characteristic.
The researchers placed 25 young male mice – aged three months, equivalent to the 20s in humans -- in cages where they had access to exercise wheels. For five weeks, the animals took advantage of the wheels to run continually. Another 25 young mice were housed in similar cages but without access to wheels.
At the end of this "endurance exercise training" period, all mice were injected with 10 mg. of methamphetamine over a 24-hour period. All the mice displayed some of the same effects of meth as seen in humans: they appeared agitated and increased their physical activity, and their body temperature rose. But in terms of what was happening in the capillaries of the brain, there was a marked difference between the mice who had been exercising extensively for the previous five weeks and those who had been sedentary.