Seattle Genetics, Inc. has announced that data from its antibody-drug conjugate (ADC) programs, SGN-35 and SGN-75, were presented at the 2009 Annual Meeting of the American Association for Cancer Research (AACR) being held in Denver, CO. Preclinical data with SGN-35 further elucidate its mechanism of action and demonstrate its superior antitumor activity in lymphoma compared with non-targeted agents. In addition, data with SGN-75 indicate its therapeutic potential in multiple types of solid tumors.
“Our increasing body of preclinical research further demonstrates the power of our ADC technology to effectively target tumor cells, deliver potent drug payloads and induce antitumor activity at well-tolerated doses,” said Clay B. Siegall, Ph.D., President and Chief Executive Officer at Seattle Genetics. “SGN-35 is in late-stage clinical trials, including an ongoing pivotal trial for Hodgkin lymphoma. We are positioning our next ADC product candidate, SGN-75, for an investigational new drug submission in the second half of 2009 for the treatment of both hematologic malignancies and solid tumors.”
SGN-35 Program
SGN-35 is an ADC utilizing Seattle Genetics' proprietary technology comprising an anti-CD30 monoclonal antibody attached to the synthetic, highly potent drug monomethyl auristatin E (MMAE) through an enzyme-cleavable linker system. The linker is designed to be stable in the bloodstream but to release the drug payload under specific conditions once inside target cells, thereby sparing non-target cells many of the toxic effects of traditional chemotherapy.