Thank parasites for making some of our immune proteins into the inflammatory defenders they are today, according to a population genetics study that will appear in the June 8 issue of the Journal of Experimental Medicine (online May 25).
The study, conducted by a team of researchers in Italy, also suggests that you might blame parasites for sculpting some of those genes into risk factors for intestinal disorders.
Parasite-driven selection leaves a footprint on our DNA in the form of mutations known as "single nucleotide polymorphisms" (SNPs). Making sure that genetic variation (in the form of multiple SNPs) is maintained within certain immune genes over time helps ensure that the host can fend off different infections in different environments.
In the new study, Matteo Fumagalli and colleagues sift through 1,052 SNPs in genes that code for immune proteins called interleukins from roughly 1000 people worldwide. Of 91 genes assessed, 44 bore signatures of evolutionary selection, meaning that the genetic variation was neither due to chance nor to the migration of populations over time. And some of that variation correlated with the diversity of parasites that live alongside humans. The data suggests that having lots of different parasites around has shaped the evolution of our interleukin genes.