Combining two chemotherapy drugs for advanced gallbladder and bile duct cancer improves survival by a third, according to results from a Cancer Research UK funded trial presented today at the American Society of Clinical Oncology (ASCO) conference*.
The trial, run by the Cancer Research UK & UCL Cancer Trials Centre**, was the largest ever phase III clinical trial for these cancers. They found that for patients receiving both gemcitabine and cisplatin it reduced the chance of the cancer growing by 28 per cent.
Also, patients given this combination of drugs lived longer - on average 11.7 months compared to 8.3 months for those on the trial receiving gemcitabine alone.
The trial, called ABC02, recruited over 400 UK patients with advanced gallbladder and bile duct cancer which can't be operated on. One group had a combination of gemcitabine and cisplatin and the second group were treated with gemcitabine alone. The treatment lasted for 24 weeks for both groups of patients.
Gallbladder and bile duct cancers are rare and very difficult to treat in the advanced stages. Of those diagnosed with the disease only around one in 10 will survive for more than five years.
Dr Juan Valle, consultant oncologist at The Christie in Manchester and co chief investigator for the trial***, said: "This important trial has shown that adding cisplatin to gemcitabine slowed cancer progression and extended survival for these rare but hard-to-treat cancers, with minimal side effects. This establishes the combination treatment cisplatin and gemcitabine as an international standard of care for patients with advanced gallbladder and bile duct cancers.