A new blood test, measuring the level of omega-3 fatty acids in red blood cells, is now broadly available for the first time to the public everywhere as a consumer-friendly, at-home "finger stick" test. While scientists have long known of the benefits of fish and fish oil for overall heart health, over the past decade research has proven that the omega-3 fatty acids found in fish dramatically reduce one's risk for cardiovascular disease. Further, recent research indicates that omega-3 levels may be among the best predictors of future coronary heart disease - providing much stronger correlations to the risk of sudden cardiac death than traditional indicators, including HDL and LDL cholesterol.
The Gene Smart Omega-3 Index measures the amount of EPA and DHA omega-3 fatty acids in red blood cell membranes and is expressed as the percent of total fatty acids. The results of the test are represented as a score that a significant body of research indicates may be an independent predictor of heart disease - with a score of 4 percent or less indicating a high risk, and a score of 8 percent or more indicating a relatively low risk.
"The research suggests that the levels of omega-3 fatty acids should be routinely measured, especially in vulnerable populations such as those at risk of cardiovascular and inflammatory diseases," said Floyd "Ski" Chilton, PhD, a pioneer in inflammatory disease and omega-3 research and a professor of Physiology and Pharmacology at Wake Forest University School of Medicine. "This test is the most convenient, affordable and effective way to measure omega-3 levels."
However, very recent studies suggest that individuals have varying capacities to metabolize omega-3s. "So even if a person eats fish or takes fish oil supplements, they may not be getting enough," Dr. Chilton added. "It is important to measure omega-3 levels, so individuals can determine whether their dietary intake of this important nutrient needs to be adjusted."
In introducing the Gene Smart Omega-3 Index, Gene Smart has partnered with a pioneer of omega-3 research and cardiovascular disease, William S. Harris, Ph.D., a professor in the Department of Internal Medicine and Basic Biomedical Sciences at the Sanford School of Medicine of the University of South Dakota and a co-author on the American Heart Association's (AHA) Scientific Advisory on Fish and Omega-3 Fatty Acids published in Circulation (Vol. 106:2002).
Dr. Harris has published over 80 scientific articles on omega-3s, including his ground-breaking study, published in Preventive Medicine (Vol. 39, 2004) with co-author Clemens von Schacky, MD, a cardiologist from Munich, which first proposed the Omega-3 Index as a cardiovascular risk factor.
The Gene Smart Omega-3 Index(TM) uses Dr. Harris's proprietary HS-Omega-3 Index(R) methodology -- the same methodology used in the clinical studies that validated the correlation between the Omega-3 Index and heart disease risk. The science behind the Index has been tested and validated by data from numerous large-scale human clinical studies, including the highly-regarded Physicians' Health Study (PHS), which involved 14,916 healthy male physicians.
"The strength of the association between omega-3s and heart disease is really quite remarkable," said Dr. Harris. "And the benefits of having a high Omega-3 Index, in the 8 to 10 percent range, speak for themselves. Individuals with a high Index have a decrease in the relative risk for sudden cardiac death by as much as 90 percent."
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