Most people might think of nettle as simply a common and aggressive weed that can sting and cause skin irritation. But nettle has also been used for hundreds of years to treat seasonal allergies and other inflammatory diseases, although the precise nature of its anti-inflammatory effect was unknown. Now, scientists with HerbalScience have identified specific bioactives in nettle leaf extracts that inhibit in vitro receptors and enzymes known to be key in generating symptoms of allergic rhinitis, or hay fever.
An article detailing the research, titled "Nettle Extract (Urtica dioica) Affects Key Receptors and Enzymes Associated with Allergic Rhinitis," has been published in the July 2009 issue of Phythotherapy Research, a peer-reviewed scientific journal. The authors are affiliated with HerbalScience Group LLC, a Naples, Florida, and Singapore-based company dedicated to applying advanced science and technology to the production of botanical drugs and nutraceuticals, and the University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
"More than 20 million people in the United States suffer from seasonal allergies," said Randall S. Alberte, Ph.D., Chief Scientific Officer of HerbalScience and one of the authors of the published study. "While there are many effective over-the-counter and prescription allergy medications on the market, the fact that some may cause undesirable side effects in some patients means there is an ongoing need to seek potential new treatments. Our research results provide, for the first time, an understanding of how nettle extracts reduce allergic responses in vitro, which could lead to new standardized botanical, non-drug therapies that are safe and effective, and that have no side effects."
The study utilized a proprietary nettle extract prepared using HerbalScience's patented extraction technologies, which standardize the chemical profile of any selected botanical in order to deliver a compositionally and functionally consistent product, batch to batch. Separate assays were conducted to determine the extent of anti-inflammatory activities of the nettle extract in targeting key cellular-level processes that generate the symptoms of allergic rhinitis. The results showed the nettle extract has multiple anti-inflammatory activities that include: